Description

Virion Host Shutoff Protein (VHS) is a key regulatory protein encoded by certain viruses, notably herpes simplex virus (HSV), which functions to shut off host cell protein synthesis and promote viral replication. This compound, identified by CAS No. 118367-50-3, is a critical reagent for advanced virology and molecular biology research, enabling the study of viral pathogenesis and host-pathogen interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on antiviral drug discovery and viral mechanism studies.

Application

• Virology Research: Fundamental studies on viral replication cycles and host cell shutoff mechanisms.
• Antiviral Drug Discovery: Screening and validation of compounds targeting viral proteins that inhibit host gene expression.
• Molecular Biology Studies: Investigation of post-transcriptional gene regulation and mRNA degradation pathways.
• Protein-Protein Interaction Analysis: Used as a bait or target protein in assays to identify host factors involved in viral infection.
• Biochemical Assay Development: Serving as a standard or active component in enzymatic and functional assays.
• Academic & Pharmaceutical R&D: Essential for basic research and the development of novel therapeutic strategies against herpesviruses and related pathogens.

Basic Information

Product Name	Virion Host Shutoff Protein
CAS No.	118367-50-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	VHS Protein; UL41 Protein; Virion Host Shutoff Factor; HSV-1 VHS; Herpes Simplex Virus Type 1 Virion Host Shutoff Protein; ICP27; mRNA Degradation Protein UL41; Host Protein Synthesis Inhibitor
EINECS	Contact for details

Quality Control

Our Virion Host Shutoff Protein is produced and handled under stringent quality protocols suitable for research applications. Each batch undergoes rigorous analytical testing, including purity assessment and functional activity verification, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For optimal stability, avoid repeated freeze-thaw cycles by aliquoting the product upon receipt.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (SDS-PAGE)	≥ 90%
Protein Content	≥ 95% (Biuret)
Biological Activity	Assay-dependent; COA provided
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.