Description

7,8-Didehydro-4,5-Epoxy-17-[Methyl-D3]Morphinan-3,6-Diol Hydrochloride: Trihydrate is a deuterated isotopologue of a key pharmaceutical intermediate, offering enhanced stability and traceability for advanced research and development. This high-purity compound is critical for applications requiring precise metabolic and pharmacokinetic studies, where the deuterium label provides distinct analytical advantages. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) for the development of novel therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the quantitative analysis of related APIs and metabolites via LC-MS and GC-MS.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify drug disposition in biological systems.
• Deuterated API Synthesis: Acts as a key labeled building block in the synthesis of deuterated drug candidates for improved metabolic stability.
• Forensic and Clinical Toxicology: Employed as a high-purity calibrant in analytical methods for the accurate detection of opioids and their derivatives.
• Regulatory Compliance Testing: Supports method development and validation for quality control in pharmaceutical manufacturing under GMP guidelines.
• Academic and Institutional Research: Facilitates fundamental research in medicinal chemistry, neuropharmacology, and analytical science.

Basic Information

Product Name	7,8-Didehydro-4,5-Epoxy-17-[Methyl-D3]Morphinan-3,6-Diol Hydrochloride: Trihydrate
CAS No.	118357-24-7
Molecular Formula	C17H16D3NO4 • HCl • 3H2O
Molecular Weight	375.83 g/mol (anhydrous free base: 285.33)
Synonyms	Morphine-17-methyl-d3 Hydrochloride Trihydrate; 17-(Trideuteriomethyl)morphine Hydrochloride Trihydrate; [Methyl-D3]Morphine Hydrochloride Trihydrate; Deuterated Morphine HCl Trihydrate; (5α,6α)-7,8-Didehydro-4,5-epoxy-17-(methyl-d3)-3,6-diol Hydrochloride Trihydrate; Morphine-N-CD3 Hydrochloride Trihydrate; Isotopically Labeled Morphine Standard.
EINECS	Contact for details

Quality Control

Our 7,8-Didehydro-4,5-Epoxy-17-[Methyl-D3]Morphinan-3,6-Diol Hydrochloride: Trihydrate is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and Karl Fischer titration for water content. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	12.0% - 15.0% (Theoretical for Trihydrate: ~14.4%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.