Description

N,o-Dimethyl-Cbz-L-Arginine is a protected derivative of the amino acid L-arginine, featuring both N-methylation and a carboxybenzyl (Cbz) protecting group. This specific chemical modification is crucial for advanced peptide synthesis, offering enhanced control over reaction selectivity and protecting sensitive functional groups during complex molecular assembly. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key protected amino acid derivative in the solid-phase and solution-phase synthesis of complex peptide drugs.
• Biochemical Research: Used as a specialized reagent in the study of enzyme-substrate interactions and the structure-activity relationships of arginine-containing peptides.
• Peptide Library Construction: Enables the introduction of methylated arginine analogs into combinatorial peptide libraries for drug discovery screening.
• API Development: Acts as a critical starting material or intermediate in the development of Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Protecting Group Strategy: The Cbz group allows for orthogonal deprotection strategies, facilitating the synthesis of peptides with multiple sensitive sites.

Basic Information

Item	Detail
Product Name	N,o-Dimethyl-Cbz-L-Arginine
CAS No.	118171-80-5
Molecular Formula	C16H24N4O4
Molecular Weight	336.39 g/mol
Synonyms	Nω-Methyl-Nω-[(benzyloxy)carbonyl]-Nδ-methyl-L-arginine; Nω-Carbobenzoxy-Nω,Nδ-dimethyl-L-arginine; Cbz-Nω,Nδ-dimethyl-L-arginine; N,N'-Dimethyl-Nα-Cbz-L-arginine; (2S)-5-[(Carbobenzyloxy)(methyl)amino]-2-(methylamino)pentanoic acid; Z-Nω,Nδ-dimethyl-L-Arg-OH; Nω-Cbz-Nω,Nδ-dimethyl-L-arginine
EINECS	Contact for details

Quality Control

Our N,o-Dimethyl-Cbz-L-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.