Description

Z-4-Amino-3-Hydroxybutyric Acid is a chiral, non-proteinogenic amino acid derivative that serves as a critical building block in organic synthesis and pharmaceutical research. Its unique stereochemistry and bifunctional amino-hydroxy acid structure make it a valuable intermediate for creating complex molecules with high biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients, chiral catalysts, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of β-lactam antibiotics, neuromodulators, and other bioactive molecules.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Peptide Mimetics & Conjugates: Used to introduce hydroxy and amino functionalities into peptide backbones, modifying stability and receptor binding.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective synthesis.
• Biochemical Research: Probe for studying enzymatic pathways involving γ-aminobutyric acid (GABA) analogs and related neurotransmitters.
• Fine Chemical Synthesis: Intermediate for producing specialty chemicals, flavors, and fragrances requiring precise stereocontrol.

Basic Information

Product Name	Z-4-Amino-3-Hydroxybutyric Acid
CAS No.	118125-41-0
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(3R,4S)-4-Amino-3-hydroxybutanoic acid; (3R,4S)-3-Hydroxy-4-aminobutanoic acid; Z-4-AHBA; (3R,4S)-AHBA; 4-Amino-3-hydroxybutyric acid (Z-isomer); L-threo-4-Amino-3-hydroxybutyric acid; (3R,4S)-3-Hydroxy-4-aminobutyric acid; 4-Amino-3-hydroxybutanoic acid (Z-form)
EINECS	Contact for details

Quality Control

Our Z-4-Amino-3-Hydroxybutyric Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (Z-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.