Description

Carbamic Acid, [(1S)-1-Methyl-2-Propynyl]-, 1,1-Dimethylethyl Ester (9Ci) is a specialized chiral building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, featuring both a carbamate protecting group and a terminal alkyne functionality, enabling precise and efficient construction of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals requiring stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in stereoselective synthesis.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is crucial for bioactivity.
• Peptide Mimetics & PROTACs: Serves as a versatile linker or building block in the design of peptide analogs and proteolysis-targeting chimeras (PROTACs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials utilizing click chemistry via its alkyne group.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands or catalysts used in enantioselective transformations.
• Chemical Biology Probes: Utilized to create labeled probes for studying biological pathways and target engagement.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-Methyl-2-Propynyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	118080-79-8
Molecular Formula	C10H17NO2
Molecular Weight	183.25 g/mol
Synonyms	(S)-1,1-Dimethylethyl (1-methyl-2-propynyl)carbamate; tert-Butyl N-[(1S)-1-methylprop-2-yn-1-yl]carbamate; (S)-tert-Butyl (1-methylprop-2-yn-1-yl)carbamate; (S)-tert-Butoxycarbonylamino-1-methyl-propyne; BOC-L-But-3-yn-2-ylamine; (S)-N-Boc-1-methylpropargylamine; (S)-1-Methyl-2-propynyl carbamic acid tert-butyl ester; (S)-1-(tert-Butoxycarbonylamino)-1-methylpropyne
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S)-1-Methyl-2-Propynyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We operate under a quality system designed to meet the rigorous standards required for pharmaceutical R&D and other high-value applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen or argon after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.