Description

(Tyr0)-Atriopeptin II (Rat) is a synthetic peptide analog of the endogenous cardiac hormone Atrial Natriuretic Peptide (ANP), specifically designed for research applications. This compound is crucial for investigating the structure-activity relationships of ANP and its role in cardiovascular physiology and renal function. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular disease, hypertension, and natriuretic peptide signaling pathways.

Application

• Biochemical Research: Used as a reference standard and tool compound in studies of natriuretic peptide receptors (NPR-A, NPR-B).
• Cardiovascular Pharmacology: Investigation of vasodilation, blood pressure regulation, and diuretic/natriuretic effects.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the bioactive core of ANP and designing novel peptide therapeutics.
• In Vitro Assay Development: Serves as a key ligand in receptor binding assays, cAMP stimulation tests, and cell-based signaling studies.
• Metabolic Pathway Analysis: Research into the role of ANP in lipid metabolism, insulin sensitivity, and energy homeostasis.
• Quality Control & Method Validation: Acts as a purity standard in analytical method development for peptide quantification (e.g., HPLC, LC-MS).

Basic Information

Item	Details
Product Name	(Tyr0)-Atriopeptin II (Rat)
CAS No.	117856-13-0
Molecular Formula	C127H204N40O41S2
Molecular Weight	2851.4 g/mol
Synonyms	Atrial Natriuretic Peptide (5-27) (rat), Tyr0-ANP (5-27) (rat), rANP (5-27) (Tyr0), Atriopeptin 21 (rat, Tyr0), H-Tyr-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23), ANP (5-27) fragment (rat), Cardionatrin I (5-27) (rat)
EINECS	Contact for details

Quality Control

Every batch of (Tyr0)-Atriopeptin II (Rat) is manufactured under strict quality protocols to ensure the highest standards of purity and consistency for research. Our products undergo rigorous analytical testing, including HPLC for purity assessment and Mass Spectrometry (MS) for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. After reconstitution, aliquot and store frozen at -80°C. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by ESI-TOF or MALDI-TOF
Purity (HPLC)	≥ 95% (UV detection at 214 nm or 280 nm)
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Water Content (K.F.)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.