Description

Bolton Hunter-Cholecystokinin Nonapeptide is a synthetic, radiolabeled peptide analog of the gastrointestinal hormone cholecystokinin (CCK). This compound is a critical research tool for studying CCK receptor binding, distribution, and function in biological systems. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers in the fields of neuroscience, gastroenterology, and oncology for receptor mapping and drug discovery applications.

Application

• Receptor Binding Assays: Used as a high-affinity radioligand for in vitro characterization of CCK receptor subtypes (CCKA and CCKB/gastrin).
• Autoradiography Studies: Enables precise anatomical localization of CCK receptors in tissue sections from brain, pancreas, and gastrointestinal tract.
• Drug Discovery & Development: Serves as a standard tracer for screening and evaluating novel therapeutic compounds targeting the CCK receptor pathways.
• Metabolic Research: Investigates the role of CCK in appetite regulation, satiety signaling, and pancreatic enzyme secretion.
• Oncology Research: Explores the expression of CCK receptors in certain tumor types for potential diagnostic or therapeutic targeting.

Basic Information

Product Name	Bolton Hunter-Cholecystokinin Nonapeptide
CAS No.	117829-67-1
Molecular Formula	C66H89N13O16S
Molecular Weight	1368.6 g/mol
Synonyms	CCK-9, Bolton-Hunter-CCK-9; Cholecystokinin Nonapeptide, Bolton-Hunter Labeled; [[(3-125I-Iodobenzoyl)amino]hexanoyl]CCK(26-33); [[125I]-(3-Iodobenzoyl)amino]hexanoyl-CCK-8; [[125I]-(3-Iodobenzoyl)amino]hexanoyl-Cholecystokinin (26-33); Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (Bolton-Hunter Derivative); Iodine-125 Labeled CCK-8; Radioiodinated CCK-8 Analog
EINECS	Contact for details

Quality Control

Our Bolton Hunter-Cholecystokinin Nonapeptide is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including radiochemical purity, specific activity, and binding affinity verification. Certificates of Analysis (COA) detailing all quality parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at or below -20°C. Due to its hygroscopic (moisture-sensitive) nature, allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term stability, store the product in the original packaging under the recommended conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Radiochemical Purity	≥ 97%
Specific Activity	~2000 Ci/mmol (74 TBq/mmol)
Solvent	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.