Description

Pth-Arginine Hydrochloride is a protected derivative of the essential amino acid L-arginine, widely utilized as a key synthetic intermediate in peptide chemistry. This compound is critical for researchers and manufacturers who require precise control over the arginine side chain during complex peptide assembly, preventing unwanted side reactions. It is primarily used in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides, research biochemicals, and advanced diagnostic agents.

Application

• Pharmaceutical Intermediates: Serves as a crucial building block in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Biochemical Research: Used in academic and industrial R&D for studying protein-protein interactions, enzyme mechanisms, and signal transduction pathways.
• API Development: Employed in the development and scale-up of Active Pharmaceutical Ingredients (APIs) where arginine incorporation with side-chain protection is required.
• Diagnostic Reagent Synthesis: Acts as a precursor in the manufacturing of labeled compounds and reagents used in immunoassays and molecular diagnostics.
• Cosmeceutical Peptides: A component in the synthesis of bioactive peptides for advanced skincare and cosmetic formulations.

Basic Information

Product Name	Pth-Arginine Hydrochloride
CAS No.	117756-28-2
Molecular Formula	C₁₃H₁₉N₅O₃S • HCl
Molecular Weight	369.84 g/mol (Free base: 333.39)
Synonyms	Nα-Pth-L-arginine hydrochloride; PTH-Arg-OH • HCl; Phthaloyl-L-arginine hydrochloride; N-Phthaloyl-L-arginine hydrochloride; L-Arginine, N2-[(phenylamino)thioxomethyl]-, monohydrochloride; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-guanidinopentanoic acid hydrochloride (common Fmoc-protected analog); Arg(Pth)-OH • HCl
EINECS	Contact for details

Quality Control

Our Pth-Arginine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	+20.0° to +24.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.