Description

Levofloxacin n-Oxide is a key pharmaceutical intermediate and metabolite of the broad-spectrum fluoroquinolone antibiotic, Levofloxacin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel antibacterial agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard suppliers, and manufacturers engaged in the production of advanced antibiotic formulations.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of advanced fluoroquinolone antibiotics.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify Levofloxacin metabolites in biological samples.
• Pharmacokinetic Research: Essential for studies investigating the absorption, distribution, metabolism, and excretion (ADME) profile of Levofloxacin.
• Impurity Profiling: Serves as a known impurity or degradation product reference in the quality control of Levofloxacin active pharmaceutical ingredients (APIs) and finished dosage forms.
• Biochemical Research: Employed in mechanistic studies to understand the antibacterial activity and resistance pathways of fluoroquinolones.
• Custom Synthesis: A starting material for the custom synthesis of labeled compounds (e.g., deuterated or C14-labeled) for advanced tracer studies.

Basic Information

Product Name	Levofloxacin n-Oxide
CAS No.	117678-38-3
Molecular Formula	C18H20FN3O5
Molecular Weight	377.37 g/mol
Synonyms	(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid N-Oxide; Levofloxacin N-Oxide Impurity; Levofloxacin Related Compound N-Oxide; (S)-(-)-Ofloxacin N-Oxide; DR-3355 N-Oxide
EINECS	Contact for details

Quality Control

Our Levofloxacin n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.