Description

Gadolinium 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-Tetraacetic Acid CAS NO 117652-04-7 is a macrocyclic gadolinium(III) complex, a critical precursor in the development of advanced magnetic resonance imaging (MRI) contrast agents. This compound is valued for its high thermodynamic and kinetic stability, which is essential for creating safer, next-generation diagnostic tools. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on medical imaging and inorganic chemistry.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing macrocyclic gadolinium-based MRI contrast agents (e.g., Gadobutrol, Gadoteridol analogs).
• Medical Imaging Research: Used in the development and study of novel T1-weighted contrast agents for enhanced tissue visualization in MRI.
• Chelation Chemistry Studies: Serves as a model compound for investigating lanthanide coordination chemistry and ligand-metal stability constants.
• Radiopharmaceutical Precursor: Potential precursor for the development of theranostic agents when paired with radioactive isotopes.
• Material Science: Component in the creation of advanced materials for molecular imaging and sensing applications.
• Quality Control Reference Standard: Used as a certified reference material for analytical method development and validation in pharmaceutical QC labs.

Basic Information

Product Name	Gadolinium 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-Tetraacetic Acid
CAS No.	117652-04-7
Molecular Formula	C22H32GdN4O8
Molecular Weight	628.77 g/mol
Synonyms	Gadolinium(III) DOTA; Gd-DOTA; Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (common alternate naming); Gadolinium tetraazacyclotetradecanetetraacetate; DOTA-Gd(III) complex; Tetraglycine gadolinium complex; Gadoterate (Gadolinium salt); (OC-6-11)-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetato(3-)-κN1,κN4,κN7,κN10,κO,κO‘]gadolinium
EINECS	Contact for details

Quality Control

Our Gadolinium DOTA is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Gadolinium (Gd) Content	24.5 - 25.5 %
pH (1% Solution)	5.0 - 7.0
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.