Description

Parathyroid Hormone (3-84) is a specific, biologically active fragment of the full-length parathyroid hormone. This high-purity peptide is critical for research into calcium and phosphate metabolism, bone physiology, and endocrine signaling pathways. It is an essential reference standard and active pharmaceutical ingredient (API) for pharmaceutical development, particularly for treatments targeting osteoporosis and parathyroid disorders. Researchers and manufacturers in biotechnology, pharmaceutical R&D, and clinical diagnostics rely on its consistent quality and biological activity.

Application

• Pharmaceutical R&D: Used as a reference standard and active pharmaceutical ingredient (API) in the development of therapies for osteoporosis, hypoparathyroidism, and other bone metabolic disorders.
• Biochemical Research: Serves as a critical tool for studying the structure-activity relationship of parathyroid hormone, its receptor binding mechanisms, and downstream signaling cascades.
• Clinical Diagnostics: Employed in the calibration and development of immunoassays and other diagnostic kits designed to measure PTH levels in patient serum.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the effects of PTH on osteoblast and osteoclast activity, renal calcium reabsorption, and vascular function.
• Peptide Chemistry & Synthesis: Acts as a benchmark compound for developing and optimizing peptide synthesis, purification, and analytical methods.

Basic Information

Product Name	Parathyroid Hormone (3-84)
CAS No.	117628-36-1
Molecular Formula	C412H672N124O126S2
Molecular Weight	~9427.7 g/mol
Synonyms	PTH (3-84); Parathyroid Hormone Fragment 3-84; Human Parathyroid Hormone (3-84); hPTH (3-84); Parathyrin (3-84); PTH 3-84; Parathyroid Hormone, Human, 3-84; CAS 117628-36-1
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (3-84) is manufactured under strict quality management systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and biological activity. Our quality commitment aligns with cGMP principles for pharmaceutical ingredients, supporting your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Peptide Content	≥ 80.0% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by in vitro cell-based assay; COA provided

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.