Description

Parathyroid Hormone-Related Protein(1-40), Tyr(40)- is a synthetic peptide fragment corresponding to the biologically active N-terminal region of the endogenous parathyroid hormone-related protein (PTHrP). This high-purity peptide is a critical research tool for studying calcium metabolism, bone biology, and the pathophysiology of humoral hypercalcemia of malignancy. It is essential for scientists and developers in pharmaceutical research, biochemical assay development, and academic life sciences who require a reliable and well-characterized reference standard.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTH/PTHrP receptor (PTH1R) signaling, bone formation, and calcium homeostasis.
• Assay Development: Serves as a critical component in the development and validation of immunoassays (ELISA, RIA) and cell-based bioassays for PTHrP detection and quantification.
• Drug Discovery: Employed in high-throughput screening (HTS) campaigns and pharmacological studies to identify and characterize novel modulators of the PTH1R pathway.
• Receptor Binding Studies: Utilized in competitive binding assays to determine receptor affinity and study structure-activity relationships (SAR) of peptide analogs.
• Academic & Clinical Research: Fundamental for investigating the role of PTHrP in cancer biology, skeletal development, and cardiovascular function.
• Quality Control: Acts as a system suitability standard in analytical laboratories for method development and quality control of related peptide therapeutics.

Basic Information

Product Name	Parathyroid Hormone-Related Protein(1-40), Tyr(40)-
CAS No.	117628-21-4
Molecular Formula	C205H325N61O60S
Molecular Weight	4678.2 g/mol
Synonyms	PTHrP(1-40), Tyr40; Parathyroid Hormone-like Protein (1-40); PTH-Related Peptide (1-40); PTHLH (1-40); Humoral Hypercalcemia of Malignancy Factor (1-40); hPTHrP(1-40); ALP (Adenylate Cyclase-Stimulating Protein); Osteostatin precursor fragment.
EINECS	Contact for details

Quality Control

Every batch of our Parathyroid Hormone-Related Protein(1-40), Tyr(40)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and biological activity. Our quality commitment aligns with standards for research-grade biochemicals. Comprehensive Certificates of Analysis (COA) detailing purity (HPLC), molecular weight confirmation (MS), and peptide content are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Stimulates cAMP production in suitable cell lines (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.