Description

5-(Acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate is a sophisticated, multi-functionalized sialic acid derivative, serving as a critical advanced intermediate in modern synthetic organic chemistry. Its value lies in its precise fluorination and acetylation pattern, which enables the controlled synthesis of biologically active molecules and complex carbohydrate mimetics. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel antiviral agents, enzyme inhibitors, and diagnostic probes targeting sialic acid-mediated biological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated sialic acid analogs and neuraminidase inhibitors for antiviral drug discovery.
• Glycobiology Research: Used to study sialic acid biology, including cell recognition, signaling, and pathogen-host interactions.
• Probe Development: Serves as a starting material for creating fluorescent or affinity-labeled sialic acid probes for diagnostic and imaging applications.
• Enzyme Substrate/Inhibitor: Acts as a substrate or inhibitor for sialidases (neuraminidases) and sialyltransferases in biochemical assays.
• Carbohydrate Chemistry: A versatile building block for the chemical and chemoenzymatic synthesis of complex oligosaccharides and glycoconjugates.
• Vaccine Adjuvant Research: Investigated for its potential role in modulating immune responses as part of synthetic antigen constructs.

Basic Information

Product Name	5-(Acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
CAS No.	117405-58-0
Molecular Formula	C24H32FNO14
Molecular Weight	577.51 g/mol
Synonyms	Methyl 5-acetamido-3,5-dideoxy-3-fluoro-α-L-manno-2-nonulopyranosidonic acid 2,4,7,8,9-pentaacetate; 3-Fluoro-5-acetamido-3,5-dideoxy-D-glycero-α-L-galacto-2-nonulopyranosonic acid methyl ester pentaacetate; 3-Fluoro-Neu5Ac methyl ester pentaacetate; Fluorinated sialic acid derivative; 3-Fluoro-N-acetylneuraminic acid methyl ester peracetate; CAS 117405-58-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Identity and purity are confirmed through a combination of advanced analytical techniques including NMR (¹H, ¹³C, ¹⁹F), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing specifications and test results is provided with each shipment to support your R&D and cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.