Description

3-(4-Fluorophenyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid is a high-value fluorinated organic building block with a unique trifluoroacetyl-protected amino acid structure. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds for advanced synthesis. It is primarily utilized by the pharmaceutical and agrochemical industries for the development of novel active ingredients, where its fluorine atoms and reactive handles enable the fine-tuning of biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, leveraging the fluorine moiety to enhance product efficacy and environmental profile.
• Peptidomimetics & PROTACs: Used in the construction of peptide analogs and Proteolysis-Targeting Chimeras (PROTACs) due to its protected amino acid functionality.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials where fluorinated aromatic groups impart specific chemical resistance or physical properties.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags or activity-based probes to study enzyme function and biological pathways.

Basic Information

Product Name	3-(4-Fluorophenyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid
CAS No.	117291-16-4
Molecular Formula	C11H9F4NO3
Molecular Weight	279.19 g/mol
Synonyms	3-Amino-3-(4-fluorophenyl)propanoic acid, N-(2,2,2-Trifluoroacetyl)-; N-Trifluoroacetyl-3-amino-3-(4-fluorophenyl)propionic Acid; 3-(4-Fluorophenyl)-3-(2,2,2-trifluoroacetamido)propanoic Acid; β-(4-Fluorophenyl)-β-[(trifluoroacetyl)amino]propionic Acid; 117291-16-4; TFAP-F; (3R/S)-3-(4-Fluorophenyl)-3-[(2,2,2-trifluoroacetyl)amino]propanoic acid (racemic mixture)
EINECS	Contact for details

Quality Control

Our production of 3-(4-Fluorophenyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system is designed to meet the rigorous standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.