Description

Barnidipine-D4 is a deuterium-labeled analog of the calcium channel blocker Barnidipine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical and biotechnology sectors for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS quantification of Barnidipine in biological matrices (plasma, serum, urine).
• Bioanalytical method development and validation in pharmaceutical R&D.
• Drug metabolism and pharmacokinetics (DMPK) studies for accurate tracer analysis.
• Clinical research and therapeutic drug monitoring (TDM) applications.
• Quality control and assurance in pharmaceutical manufacturing processes.
• Metabolite identification and profiling studies.

Basic Information

Product Name	Barnidipine-D4
CAS No.	117152-15-5
Molecular Formula	C27H31D4N3O6
Molecular Weight	~ 493.60 g/mol
Synonyms	Barnidipine-d4; Mepirodipine-d4; YM-09730-5-d4; (±)-Barnidipine-d4; 3-(1-Benzyl-3-piperidinyl) 5-isopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate-d4; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-benzyl-3-piperidinyl) ester 5-(1-methylethyl) ester-d4
EINECS	Contact for details

Quality Control

Our Barnidipine-D4 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.