Description

Boc-L-2,4-Diaminobutyric Acid(Fmoc) CAS NO 117106-21-5 is a protected, orthogonally functionalized amino acid derivative essential for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during solid-phase and solution-phase peptide assembly. It is primarily utilized in the pharmaceutical, biotechnology, and academic research sectors for the development of novel peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of a free diamine side chain, enabling the synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the research and development of active pharmaceutical ingredients (APIs), particularly for oncology and metabolic disorder treatments.
• Bioconjugation and Linker Chemistry: Used to create functionalized linkers for attaching peptides to surfaces, carriers, or other biomolecules in drug delivery systems and diagnostic assays.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions, enzyme activity, and cellular pathways.
• Antibiotic and Antimicrobial Peptide Research: A valuable component in the design and synthesis of novel antimicrobial peptides (AMPs) due to its unique diaminobutyric acid backbone.
• Custom Peptide Service Providers: A staple reagent for CROs and CDMOs offering bespoke peptide manufacturing services to the global life sciences market.

Basic Information

Product Name	Boc-L-2,4-Diaminobutyric Acid(Fmoc)
CAS No.	117106-21-5
Molecular Formula	C₂₀H₂₈N₂O₆
Molecular Weight	392.45 g/mol
Synonyms	Nα-Boc-Nδ-Fmoc-L-2,4-diaminobutyric acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid; Boc-Dab(Fmoc)-OH; Fmoc-L-Dab(Boc)-OH; Nδ-Fmoc-Nα-Boc-L-2,4-diaminobutyric acid; L-2,4-Diaminobutyric acid, Nα-Boc, Nδ-Fmoc; Boc-L-Dab(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our Boc-L-2,4-Diaminobutyric Acid(Fmoc) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); desiccate upon opening and minimize exposure to ambient humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.