Description

Boc-D-3,3-Diphenylalanine is a high-purity, non-natural amino acid derivative featuring a diphenylmethyl side chain and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of sterically demanding, hydrophobic motifs. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates targeting protein-protein interactions and metabolic disorders.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-3,3-diphenylalanine residue.
• Peptidomimetic Design: Serves as a backbone for designing and synthesizing peptidomimetics with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: A valuable precursor for creating inhibitors of enzymes like renin, HIV protease, and other aspartic proteases.
• Chemical Biology Research: Tool compound for studying peptide structure-activity relationships (SAR) and receptor-ligand interactions.
• Material Science: Potential monomer for creating specialty polymers with unique aromatic and chiral properties.

Basic Information

Product Name	Boc-D-3,3-Diphenylalanine
CAS No.	117027-46-0
Molecular Formula	C₂₆H₂₇NO₄
Molecular Weight	417.50 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-3,3-diphenylalanine; Boc-D-3,3-Diphenyl-Ala-OH; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3,3-diphenylpropanoic acid; N-Boc-D-3,3-diphenylalanine; tert-Butyl (R)-(3,3-diphenyl-1-carboxypropyl)carbamate; Boc-D-Diphenylalanine; D-3,3-Diphenylalanine Boc derivative
EINECS	Contact for details

Quality Control

Our Boc-D-3,3-Diphenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.