Description

Nicotinamide-Adenine Dinucleotide 2',3'-Dialdehyde is a chemically modified derivative of the essential coenzyme NAD+, featuring reactive aldehyde groups at the 2' and 3' positions of the adenosine ribose moiety. This modification makes it a valuable biochemical cross-linking agent and affinity labeling reagent, crucial for probing enzyme active sites and studying nucleotide-protein interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in advanced enzymology and molecular biology.

Application

• Enzyme Active Site Mapping: As an affinity label to covalently modify and identify critical amino acid residues in dehydrogenase and other NAD(P)-dependent enzymes.
• Bioconjugation and Cross-linking: For creating stable conjugates between proteins, nucleic acids, or other biomolecules bearing primary amine groups.
• Structural Biology Studies: To investigate the binding pockets and cofactor interaction mechanisms within protein structures.
• Diagnostic Reagent Synthesis: Used in the development and manufacturing of specialized diagnostic assays and biosensors.
• Pharmaceutical Research: As a tool compound in drug discovery for target validation and mechanism-of-action studies.
• Biochemical Probe Development: For creating labeled NAD+ analogs to study cellular metabolism and signaling pathways.

Basic Information

Item	Details
Product Name	Nicotinamide-Adenine Dinucleotide 2',3'-Dialdehyde
CAS No.	117017-91-1
Molecular Formula	C21H26N7O14P2
Molecular Weight	662.42 g/mol
Synonyms	NAD 2',3'-Dialdehyde; Oxidized Nicotinamide Adenine Dinucleotide 2',3'-Dialdehyde; 2',3'-Di-aldehyde-NAD+; Adenosine 2',3'-Dialdehyde, 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt; Periodate-oxidized NAD+; NAD(P)+ Analog
EINECS	Contact for details

Quality Control

Our Nicotinamide-Adenine Dinucleotide 2',3'-Dialdehyde is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0 %
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.