Description

(14R)-14-Hydroxy Clarithromycin is a key intermediate and metabolite in the synthesis and metabolic pathway of the macrolide antibiotic clarithromycin. This compound matters for its critical role in pharmaceutical research, development, and quality control processes, serving as a reference standard and a precursor. It is primarily needed by manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors focused on antibiotic production and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of clarithromycin and related macrolide antibiotics.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of clarithromycin APIs and finished dosage forms.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, efficacy, and safety profile of clarithromycin.
• Impurity Profiling: Serves as a known impurity or degradation product marker to ensure the purity and stability of clarithromycin batches.
• Biochemical Research: Utilized in studies investigating the mechanism of action and bacterial resistance to macrolide antibiotics.

Basic Information

Item	Detail
Product Name	(14R)-14-Hydroxy Clarithromycin
CAS No.	116836-41-0
Molecular Formula	C38H69NO13
Molecular Weight	747.97 g/mol
Synonyms	14(R)-Hydroxyclarithromycin; 14-Hydroxy Clarithromycin; Clarithromycin 14-Hydroxy Metabolite; 6-O-Methylerythromycin 14-Hydroxy Derivative; 14(R)-Hydroxy-6-O-methylerythromycin A; N-Demethyl-14-hydroxyclarithromycin (related); A-62671 (Metabolite); 14-OH Clarithromycin
EINECS	Contact for details

Quality Control

Our (14R)-14-Hydroxy Clarithromycin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-purity standards suitable for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.