Description

Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide fragment corresponding to a specific regulatory region of the CaMKII enzyme. This high-purity biochemical is critical for fundamental research into calcium/calmodulin-dependent signal transduction pathways. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neuroscience, cardiology, and cellular biology.

Application

• Biochemical Research: Used as a substrate, inhibitor, or standard in enzymatic assays to study CaMKII activity and regulation.
• Antibody Production: Serves as a specific antigen for generating and characterizing antibodies against the CaMKII protein.
• Signal Transduction Studies: Essential for investigating the role of CaMKII in cellular processes like synaptic plasticity, memory formation, and muscle contraction.
• Drug Discovery Screening: Employed in high-throughput screening platforms to identify novel modulators or inhibitors of CaMKII for therapeutic development.
• Diagnostic Development: Potential use in developing assays to detect CaMKII-related biomarkers in research settings.
• Cell Biology: Used in studies involving intracellular calcium signaling and its downstream effects on gene expression and cell function.

Basic Information

Product Name	Calmodulin-Dependent Protein Kinase II (281-309)
CAS No.	116826-37-0
Molecular Formula	C142H238N44O43S
Molecular Weight	3296.8 g/mol
Synonyms	CaMKII (281-309); CaMKII Inhibitory Peptide (281-309); Autocamtide-2 Related Inhibitory Peptide (AIP); CaM Kinase II Substrate Peptide (281-309); CaMKII-derived Peptide; Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha (281-309); KN-62 Related Peptide; CaMKII Regulatory Domain Peptide
EINECS	Contact for details

Quality Control

Every batch of Calmodulin-Dependent Protein Kinase II (281-309) is manufactured under strict quality protocols. The product undergoes comprehensive analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation, to ensure it meets the exacting standards required for critical research applications. A detailed Certificate of Analysis (COA) specifying purity, amino acid analysis, and peptide content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ± 10% of theoretical
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.