Description

S-(+)-N,n-Dimethyl-3-Hydroxy-3-(2-Thienyl)-1-Propylamide is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because its defined stereochemistry and functional groups make it a critical building block for creating active pharmaceutical ingredients (APIs) with specific and potent biological activity. Pharmaceutical R&D and manufacturing teams need this precise chemical to develop and produce advanced therapeutic agents, particularly in neurological and psychiatric drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel central nervous system (CNS) active drugs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of new therapeutic candidates targeting specific receptors.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecules with high enantiomeric purity.
• Neurological Research: Employed in preclinical studies and the development of compounds for treating neurological and psychiatric disorders.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	S-(+)-N,n-Dimethyl-3-Hydroxy-3-(2-Thienyl)-1-Propylamide
CAS No.	116817-84-6
Molecular Formula	C11H17NO2S
Molecular Weight	227.32 g/mol
Synonyms	(S)-(+)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol, N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propylamine, (S)-3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-ol, (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propan-1-amine, (S)-3-Hydroxy-3-(2-thienyl)-N,N-dimethylpropanamide (common misnomer), S-DMHP, A potential intermediate for Duloxetine synthesis
EINECS	Contact for details

Quality Control

Our S-(+)-N,n-Dimethyl-3-Hydroxy-3-(2-Thienyl)-1-Propylamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98.0% by HPLC), chiral purity (≥99.0% ee), and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.