Description

Boc-Glu(Pip)-Oh is a protected amino acid derivative, specifically a γ-glutamyl peptide building block where the α-carboxyl group is free and the α-amino group is protected by a tert-butyloxycarbonyl (Boc) group. This compound is a crucial intermediate in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Peptide Synthesis Intermediate: A key building block for the controlled incorporation of glutamic acid into peptide chains during SPPS (Solid-Phase Peptide Synthesis) and solution-phase methods.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates targeting various diseases.
• Bioconjugation: Serves as a linker or spacer molecule in the conjugation of peptides to other biomolecules, dyes, or solid supports due to its reactive carboxyl group.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme activity.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse libraries of glutamic acid-containing compounds for high-throughput screening.

Basic Information

Product Name	Boc-Glu(Pip)-Oh
CAS No.	116596-43-1
Molecular Formula	C₁₆H₂₈N₂O₆
Molecular Weight	344.41 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-glutamic acid α-piperidide; Boc-L-Glu(O-Pip)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-5-oxo-5-(piperidin-1-yl)pentanoic acid; Boc-Glu(O-Pip)-OH; Boc-Glutamic acid piperidyl amide; Boc-L-Glutamic Acid 1-Piperidide; tert-Butyloxycarbonyl-L-glutamic acid piperidyl amide; N-Boc-L-glutamic acid piperidyl amide
EINECS	Contact for details

Quality Control

Our Boc-Glu(Pip)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.