Description

Antithrombin Iii Northwick Park is a highly purified, functionally active form of the serine protease inhibitor Antithrombin III (ATIII), a critical regulator of the blood coagulation cascade. This specific preparation is essential for research and development in hemostasis and thrombosis, providing a reliable reference standard for diagnostic assays and therapeutic studies. It is primarily utilized by pharmaceutical R&D teams, clinical diagnostics manufacturers, and academic researchers focused on cardiovascular diseases and anticoagulant therapies.

Application

• Reference Standard for Diagnostic Kits: Serves as a critical calibrant and control material in the production and validation of clinical diagnostic assays for Antithrombin III deficiency.
• Biochemical Research: Used in in vitro studies to investigate the mechanisms of blood coagulation, fibrinolysis, and the interaction with heparin and other glycosaminoglycans.
• Therapeutic Development: Acts as a key starting material or comparator in the research and development of plasma-derived or recombinant Antithrombin III replacement therapies.
• Quality Control in Plasma Fractionation: Employed as a standard to monitor the potency and functional activity of Antithrombin III concentrates during manufacturing.
• Academic & Clinical Studies: Facilitates research into thrombotic disorders, sepsis, and other conditions associated with Antithrombin III pathway dysregulation.

Basic Information

Product Name	Antithrombin Iii Northwick Park
CAS No.	116549-74-7
Molecular Formula	C₁₃₈₀H₂₁₆₈N₃₈₂O₄₄₂S₁₈
Molecular Weight	~58,200 Da
Synonyms	Antithrombin III (Human); ATIII; Serpin C1; Heparin Cofactor I; Antithrombin-III Northwick Park Mutant; AT III; Antithrombin; Antithrombin 3; Antithrombin III, plasma protease inhibitor; Antithrombin III Budapest; Antithrombin III Basel
EINECS	Contact for details

Quality Control

Our Antithrombin Iii Northwick Park is manufactured under strict quality systems. Each batch is characterized for identity, purity, and functional heparin cofactor activity to ensure it meets the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by SDS-PAGE and HPLC), specific activity, and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to standard
Purity (HPLC)	≥ 95%
Specific Activity	≥ 5.0 IU/mg protein
Protein Content (Biuret)	Contact for details
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in water or buffered saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.