Description

n-Methoxy-n-Methyl-2-(Trifluoromethyl)Benzamide is a specialized, high-value chemical building block featuring a Weinreb amide moiety and a trifluoromethyl aromatic group. This compound is of significant importance in modern synthetic organic chemistry, particularly for the controlled introduction of ketone functionalities via nucleophilic addition. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethylated aromatic ketone structures.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and metabolic stability.
• Weinreb Amide Applications: Serves as a versatile reagent for the controlled formation of ketones from organometallic reagents like Grignard or organolithium compounds, preventing over-addition.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals, where the trifluoromethyl group can influence electronic properties and stability.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	n-Methoxy-n-Methyl-2-(Trifluoromethyl)Benzamide
CAS No.	116332-63-9
Molecular Formula	C11H12F3NO2
Molecular Weight	247.21 g/mol
Synonyms	2-(Trifluoromethyl)-N-methoxy-N-methylbenzamide; N-Methoxy-N-methyl-2-(trifluoromethyl)benzamide; N,2-Dimethoxy-N-methyl-2-(trifluoromethyl)benzamide (incorrect but common); Weinreb amide of 2-(trifluoromethyl)benzoic acid; 2-Trifluoromethylbenzoic acid N-methoxy-N-methylamide; α,α,α-Trifluoro-o-toluic acid N-methoxy-N-methylamide
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methyl-2-(Trifluoromethyl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC/HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.