Description

n-Methoxy-n-Methyl-3-(Trifluoromethyl)Benzenecarboxamide is a specialized chemical building block, also known as a Weinreb amide derivative of 3-(trifluoromethyl)benzoic acid. Its primary value lies in its role as a versatile and stable intermediate for the controlled synthesis of ketones and aldehydes in complex organic sequences. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where the introduction of the trifluoromethyl group is a key strategy for modulating the biological activity and metabolic stability of target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) containing aryl ketone or aldehyde functionalities, particularly those with trifluoromethyl substituents for enhanced lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group contributes to efficacy and environmental persistence.
• Material Science Research: Serves as a building block for novel organic materials, such as liquid crystals or polymers, where specific aromatic ketone structures are required.
• Cross-Coupling Reactions: Acts as a stable amide partner in transition-metal-catalyzed cross-coupling reactions, enabling the construction of complex biaryl systems.
• Medicinal Chemistry & Drug Discovery: A valuable tool in parallel synthesis and library development for creating diverse compound sets for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	n-Methoxy-n-Methyl-3-(Trifluoromethyl)Benzenecarboxamide
CAS No.	116332-62-8
Molecular Formula	C11H12F3NO2
Molecular Weight	247.21 g/mol
Synonyms	N-Methoxy-N-methyl-3-(trifluoromethyl)benzamide; 3-(Trifluoromethyl)-N-methoxy-N-methylbenzamide; N-Methoxy-N-methyl-α,α,α-trifluoro-m-toluamide; Weinreb amide of 3-(trifluoromethyl)benzoic acid; 3-(Trifluoromethyl)benzoic acid N-methoxy-N-methylamide; m-(Trifluoromethyl)benzoic acid N,O-dimethylhydroxamate; N,3-Bis(trifluoromethyl)benzamide (incorrect but common missearch); N-MOM-3-trifluoromethylbenzamide
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methyl-3-(Trifluoromethyl)Benzenecarboxamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.