Description

Sarafotoxin S6B is a highly potent and selective endothelin receptor agonist, a peptide toxin originally isolated from the venom of the burrowing asp (Atractaspis engaddensis). This compound is of significant value in cardiovascular and pharmacological research due to its ability to induce powerful and sustained vasoconstriction. It serves as a critical research tool for scientists and pharmaceutical developers studying endothelin receptor function, signal transduction pathways, and models of hypertension and vascular disease.

Application

• Pharmacological Research: Used as a standard agonist to study endothelin receptor (ETA and ETB) binding, activation, and downstream signaling cascades in vitro and in vivo.
• Cardiovascular Studies: Employed to establish experimental models of hypertension, vasospasm, and myocardial ischemia due to its potent vasoconstrictive properties.
• Drug Discovery & Development: Serves as a key reference compound for screening and characterizing novel endothelin receptor antagonists and modulators.
• Toxicology & Venom Research: Studied for its role in the pathophysiology of envenomation by Atractaspis species and for understanding snake venom peptide evolution.
• Cell Biology & Physiology: Applied in assays investigating smooth muscle contraction, endothelial cell function, and cellular calcium mobilization.
• Biochemical Standard: Utilized as a high-purity calibrant or reference material in analytical method development for peptide quantification.

Basic Information

Product Name	Sarafotoxin S6B
CAS No.	116303-65-2
Molecular Formula	C119H177N35O32S4
Molecular Weight	2694.1 g/mol
Synonyms	Sarafotoxin S6b; Sarafotoxin S6b (Atractaspis engaddensis); SRTX S6B; S6B; Endothelin-like peptide; ET-1 like toxin; [Cys1,3,11,15, Ala7]endothelin-1; L-Cysteinyl-L-cysteinyl-L-seryl-L-cysteinyl-L-prolyl-L-lysyl-L-tryptophyl-L-cysteinyl-L-aspartyl-L-leucyl-L-aspartyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-glutaminyl-L-tryptophyl-L-valyl-L-aspartyl-L-threonyl-L-phenylalanyl-L-cysteinyl-L-histionyl-L-leucyl-L-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-lysine cyclic (1-15,3-11)-bis(disulfide)
EINECS	Contact for details

Quality Control

Our Sarafotoxin S6B is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) documenting purity, peptide content, and endotoxin levels is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below in a dry environment. For long-term storage, consider conditions at -80°C. Solutions should be prepared in appropriate buffers (e.g., acetic acid) and stored as aliquots at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.