Description

Bothropstoxin is a potent phospholipase A2 (PLA2) enzyme isolated from the venom of the *Bothrops* genus of pit vipers. This highly specific biochemical tool is critical for research into inflammatory pathways, neuromuscular function, and the development of novel antivenoms and therapeutic agents. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on enzymology, toxicology, and drug discovery.

Application

• Biochemical Research: Used as a standard phospholipase A2 enzyme to study lipid metabolism, membrane dynamics, and eicosanoid biosynthesis pathways.
• Toxicology & Venom Studies: Serves as a key reference toxin for investigating the mechanisms of snake venom action, enabling comparative studies and antivenom efficacy testing.
• Pharmacological Screening: Employed in high-throughput assays to identify and evaluate potential PLA2 inhibitors for anti-inflammatory drug development.
• Neuroscience Research: Utilized to study presynaptic neurotoxicity and its effects on neurotransmitter release at neuromuscular junctions.
• Diagnostic Reagent Development: Acts as a component in the development of enzymatic assays and diagnostic kits for clinical and research purposes.
• Academic & Educational Use: Provided as a purified enzyme for advanced coursework and laboratory experiments in biochemistry and molecular biology.

Basic Information

Product Name	Bothropstoxin
CAS No.	116189-59-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BthTX-I; Bothropstoxin I; Phospholipase A2 Bothropstoxin; PLA2 from *Bothrops jararacussu*; Presynaptic neurotoxin; β-neurotoxin; Myotoxin I; Acidic phospholipase A2; EC 3.1.1.4
EINECS	Contact for details

Quality Control

Our Bothropstoxin is produced and purified under stringent conditions to ensure high biological activity and lot-to-lot consistency. Each batch is characterized using advanced analytical techniques, including HPLC for purity and enzymatic activity assays. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and analytical methods is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Protein Content (BCA)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers or saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.