Description

Insulin, Trp(A19)- CAS NO 116111-29-6 is a chemically modified insulin analogue where the alanine residue at position A19 is substituted with tryptophan. This engineered peptide is a critical research-grade biochemical tool for investigating insulin receptor binding, signal transduction pathways, and the development of novel therapeutic agents. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotech companies focused on endocrinology, diabetes research, and metabolic disease studies.

Application

• Biochemical Research: Fundamental studies on insulin's structure-activity relationship (SAR) and receptor interaction mechanisms.
• Pharmaceutical Development: Serves as a reference standard and key intermediate in the R&D pipeline for novel insulin-based therapeutics.
• Metabolic Disease Studies: Used in in vitro and in vivo models to understand diabetes pathophysiology and evaluate potential treatments.
• Receptor Binding Assays: Critical component in competitive binding assays to measure the affinity of new compounds for the insulin receptor.
• Academic & Educational Use: Employed in university laboratories for advanced teaching and research in peptide chemistry and endocrinology.
• Quality Control Reference: Acts as a high-purity standard for analytical method development and validation in QC laboratories.

Basic Information

Item	Detail
Product Name	Insulin, Trp(A19)-
CAS No.	116111-29-6
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Trp(A19)-Insulin; [TrpA19]-Insulin; Insulin (human) Trp-A19; Insulin A19-Tryptophan analogue; A19-Trp-Insulin; Insulin variant Trp(A19); Insulin analogue (A19Trp)
EINECS	Contact for details

Quality Control

Our Insulin, Trp(A19)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and biological activity assays to ensure consistency and performance for research applications. A detailed Certificate of Analysis (COA) documenting purity, peptide content, and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.