Description

1-Cbz-4-(2-Hydroxy-Ethyl)-Piperidine is a versatile and high-purity piperidine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in the orthogonal protection of the piperidine nitrogen by the Cbz (carboxybenzyl) group and the presence of a reactive hydroxymethyl side chain, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and receptor-targeted therapies.
• Peptidomimetic Synthesis: Used to incorporate constrained, nitrogen-containing heterocycles into peptide backbones to enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring functionalized piperidine scaffolds.
• Academic & R&D: Used in research laboratories for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	1-Cbz-4-(2-Hydroxy-Ethyl)-Piperidine
CAS No.	115909-91-6
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-(2-hydroxyethyl)piperidine; 4-(2-Hydroxyethyl)-1-piperidinecarboxylic Acid Benzyl Ester; 1-Carbobenzoxy-4-(2-hydroxyethyl)piperidine; N-Cbz-4-(2-Hydroxyethyl)piperidine; 1-N-Cbz-4-(2-Hydroxyethyl)piperidine; Benzyl 4-(2-Hydroxyethyl)piperidine-1-carboxylate; 1-(Benzyloxycarbonyl)-4-(2-hydroxyethyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-Cbz-4-(2-Hydroxy-Ethyl)-Piperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for research and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.