Description

Conotoxin Gs CAS NO 115757-31-8 is a highly specific, disulfide-rich peptide toxin derived from the venom of marine cone snails. This compound is of significant value in neuroscience and pharmaceutical research due to its potent and selective antagonism of neuronal nicotinic acetylcholine receptors (nAChRs). It serves as an indispensable pharmacological tool for researchers and developers in the fields of neuropharmacology, pain management, and the discovery of novel therapeutic agents targeting ion channels.

Application

• Neuroscience Research: As a selective probe for studying the structure, function, and distribution of specific subtypes of neuronal nicotinic acetylcholine receptors.
• Drug Discovery & Development: Used in high-throughput screening assays and as a lead compound for developing new analgesics and neuroprotective agents.
• Pharmacological Studies: Investigating synaptic transmission, receptor-ligand interactions, and the pathophysiology of neurological disorders.
• Biochemical Reagent: Employed in protein-protein interaction studies, receptor isolation, and characterization experiments.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on ion channel biology and venom-derived therapeutics.

Basic Information

Product Name	Conotoxin Gs
CAS No.	115757-31-8
Molecular Formula	C95H146N30O29S7
Molecular Weight	~2350.8 g/mol
Synonyms	Conotoxin Gs; ω-Conotoxin Gs; Conus geographus toxin Gs; μ-Conotoxin Gs; Geographutoxin I; Gs Conotoxin; α-conotoxin Gs; Neuronal Nicotinic Acetylcholine Receptor Antagonist Gs; 115757-31-8
EINECS	Contact for details

Quality Control

Our Conotoxin Gs is produced and controlled under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and biological activity assays. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Specified activity confirmed by assay
Single-Strand Content (HPLC)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.