Description

Argipressin, Thr(10)-Ser(11)-Ala(12)- CAS NO 115712-78-2 is a synthetic analog of the neurohypophysial hormone arginine vasopressin, specifically modified at positions 10, 11, and 12. This peptide is of significant interest in advanced biochemical and pharmacological research due to its potential for altered receptor binding affinity and metabolic stability compared to the native hormone. It serves as a critical tool for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on neuroendocrinology, cardiovascular research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies for investigating vasopressin receptor (V1a, V1b, V2) signaling pathways.
• Biochemical Assay Development: Serves as a key ligand in the development and validation of high-throughput screening (HTS) assays and radioimmunoassays (RIA) for drug discovery programs.
• Metabolic Studies: Employed in research to study the structure-activity relationship (SAR) of vasopressin analogs, focusing on their stability, clearance, and enzymatic degradation profiles.
• Academic Research: A vital reagent for university and institutional labs studying central and peripheral effects of vasopressin, including water homeostasis, blood pressure regulation, and social behavior.
• Peptide Chemistry & Synthesis: Used as a model compound in process development for solid-phase peptide synthesis (SPPS) and purification techniques.

Basic Information

Product Name	Argipressin, Thr(10)-Ser(11)-Ala(12)- CAS NO 115712-78-2
CAS No.	115712-78-2
Molecular Formula	C46H65N15O12S2
Molecular Weight	1052.2 g/mol
Synonyms	[Thr4, Ser5, Ala6]-Argipressin; [4-Threonine, 5-Serine, 6-Alanine]-Vasopressin; Argipressin (4-9) fragment analog; AVP analog; 1-(3-Mercaptopropanoic acid)-2-(O-methyl-L-tyrosine)-8-L-arginine-vasopressin (modified); Desmopressin related analog; Vasopressin, 4-L-threonine-5-L-serine-6-L-alanine-; Cyclo(1-6)-L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-L-glycinamide (modified sequence).
EINECS	Contact for details

Quality Control

Our Argipressin, Thr(10)-Ser(11)-Ala(12)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, mass spectrometry (MS) for molecular weight verification, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. For cGMP-grade material or specific pharmacopeial standards (e.g., USP reference standards), please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak matches theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.