Description

Boc-L-Leu-Nitrile CAS NO 115654-59-6 is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of L-leucine nitrile. This compound serves as a crucial chiral building block in the synthesis of complex peptides, peptidomimetics, and other bioactive molecules, offering a versatile handle for further chemical elaboration. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediates: A key chiral synthon in the multi-step synthesis of peptide-based drugs and therapeutic agents.
• Peptide Synthesis: Used as a protected amino acid precursor in solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of novel protease inhibitors or receptor ligands.
• Bioconjugation: Acts as a starting material for creating specialized linkers or functionalized biomolecules.
• Chemical Biology Probes: Utilized in the synthesis of labeled peptides or activity-based probes for biochemical assays.
• Asymmetric Synthesis: Serves as a chiral pool reagent for the construction of non-proteinogenic amino acids and other complex chiral structures.

Basic Information

Product Name	Boc-L-Leu-Nitrile
CAS No.	115654-59-6
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-leucine nitrile; Boc-Leu-CN; (S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanenitrile; N-Boc-L-leucine nitrile; tert-Butyl (S)-(1-cyano-3-methylbutyl)carbamate; Boc-L-leucinenitrile; (S)-2-(Boc-amino)-4-methylvaleronitrile
EINECS	Contact for details

Quality Control

Our Boc-L-Leu-Nitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.