Description

Chromogranin A (116-301) is a specific, well-characterized peptide fragment derived from the larger chromogranin A protein, a key member of the granin family of acidic secretory proteins. This fragment is of significant value in biochemical and pharmaceutical research, particularly for its role in studying neuroendocrine secretion, granin protein function, and as a potential biomarker. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in neuroscience, endocrinology, and oncology research to develop assays and investigate secretory pathways.

Application

• Biochemical Research: Used as a standard or antigen in studies investigating the structure, function, and processing of chromogranin A and related granins.
• Immunoassay Development: Serves as a critical component (antigen) for the production and calibration of antibodies in ELISA, RIA, and other immunoassay kits targeting chromogranin A fragments.
• Neuroscience & Endocrinology: Applied in research models to understand neuroendocrine secretion, hormone co-storage, and granule biogenesis.
• Biomarker Studies: Investigated as a potential circulating biomarker for neuroendocrine tumors (NETs) and other conditions involving chromogranin A secretion.
• Pharmaceutical R&D: Utilized in drug discovery programs targeting secretory pathways or chromogranin A-derived peptides.
• Quality Control Reference: Acts as a reference standard for quality control in diagnostic manufacturing and research reagent production.

Basic Information

Product Name	Chromogranin A (116-301)
CAS No.	115630-43-8
Molecular Formula	C885H1386N248O265S5
Molecular Weight	~19900 Da (Theoretical)
Synonyms	Chromogranin A Fragment 116-301; CgA (116-301); Human Chromogranin A (116-301); Pancreastatin-containing fragment; Chromogranin A Peptide; CgA 116-301; Chromogranin-A (116-301) (human); Parastatin (human) precursor fragment
EINECS	Contact for details

Quality Control

Our Chromogranin A (116-301) is produced and tested under stringent conditions to ensure high purity, identity, and batch-to-batch consistency suitable for critical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry data. We adhere to rigorous quality management protocols to support our commitment to supplying reliable research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Solubility	Soluble in water or dilute acetic acid
Endotoxin Level	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.