Description

4-Bromo-1-Ethoxy-2-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and an ethoxy substituent, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atom can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating fluorinated organic electronic materials used in displays and lighting technologies.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid molecular diversification.
• Chemical Research & Process Development: Employed in academic and industrial laboratories for method development and exploring new synthetic pathways in fluorine chemistry.

Basic Information

Product Name	4-Bromo-1-Ethoxy-2-Fluorobenzene
CAS No.	115467-08-8
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-Bromo-4-ethoxy-3-fluorobenzene; 3-Fluoro-4-bromophenetole; 4-Bromo-2-fluoroanisole; 2-Fluoro-4-bromophenetole; 4-Bromo-2-fluoro-1-ethoxybenzene; 2-Fluoro-4-bromo-1-ethoxybenzene; Benzene, 4-bromo-1-ethoxy-2-fluoro-; 115467-08-8
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Ethoxy-2-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We are committed to meeting the stringent requirements of research and cGMP-grade production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.