Description

n-Cbz-Dl-3-Hydroxy-Phenylalanine is a protected derivative of the non-natural amino acid 3-hydroxy-DL-phenylalanine, serving as a crucial chiral building block in advanced organic synthesis. This compound is valued for its role in introducing the 3-hydroxyphenyl moiety into peptide chains and complex molecules while providing orthogonal protection for the amine group. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the 3-hydroxyphenylalanine residue into peptide sequences.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the design of synthetic amino acid analogs.
• Protecting Group Chemistry: The Cbz (carboxybenzyl) group allows for selective deprotection strategies in multi-step synthetic routes.
• Ligand and Probe Development: Useful in creating specialized ligands for biochemical assays or molecular imaging probes.

Basic Information

Product Name	n-Cbz-Dl-3-Hydroxy-Phenylalanine
CAS No.	115329-02-7
Molecular Formula	C₁₇H₁₇NO₅
Molecular Weight	315.32 g/mol
Synonyms	N-Carboxybenzyl-DL-3-Hydroxyphenylalanine; N-Cbz-DL-3-Hydroxy-Phe-OH; Benzyl N-[(RS)-1-Carboxy-2-(3-hydroxyphenyl)ethyl]carbamate; DL-3-Hydroxyphenylalanine N-Carboxybenzyl Derivative; (RS)-2-[[(Benzyloxy)carbonyl]amino]-3-(3-hydroxyphenyl)propanoic acid; Nα-Cbz-3-Hydroxy-DL-phenylalanine; Z-DL-3-Hydroxy-Phe-OH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.