Description

1,2-Dipalmitoyl- Sn -Glycero-3-Phosphoethanolamine-n-(Hexanoylamine) is a synthetic, functionalized phospholipid derivative, specifically a PE (phosphatidylethanolamine) lipid conjugated with a hexanoylamine group. This compound is a critical building block in advanced lipid-based formulations, offering a reactive amine handle for further chemical conjugation. It is essential for researchers and formulators developing next-generation drug delivery systems, such as targeted liposomes and lipid nanoparticles (LNPs), where precise surface modification is required for enhanced stability, targeting, or stealth properties.

Application

• Lipid Nanoparticle (LNP) Formulation: A key functional component for creating targeted or PEGylated lipid shells in mRNA, siRNA, and gene therapy delivery vehicles.
• Liposome Surface Engineering: Used to conjugate targeting ligands (e.g., antibodies, peptides, folates) or imaging agents to the surface of liposomes for active drug targeting.
• Bioconjugation & Probe Synthesis: The reactive amine group serves as an anchor point for attaching fluorescent dyes, biotin, or other molecular probes for diagnostic and research applications.
• Model Membrane Studies: Employed in biophysical research to create asymmetric or functionalized lipid bilayers for studying membrane protein interactions and dynamics.
• Stabilizer for Nanoemulsions: Acts as a co-emulsifier and stabilizer in pharmaceutical and cosmetic nanoemulsions, improving droplet integrity and payload retention.
• Biomimetic Material Fabrication: A precursor for creating functionalized coatings and materials that mimic biological membranes for sensor and implant technology.

Basic Information

Product Name	1,2-Dipalmitoyl- Sn -Glycero-3-Phosphoethanolamine-n-(Hexanoylamine)
CAS No.	115288-21-6
Molecular Formula	C43H85N2O9P
Molecular Weight	805.11 g/mol
Synonyms	DPPE-Hexanoylamine; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(hexanoylamine); N-Hexanoyl-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; PE Lipid Conjugate; Hexanoylamine-DPPE; N-(6-Oxohexyl)-DPPE; Functionalized DPPE; Amine-reactive phospholipid; 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(6-oxohexyl)
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl- Sn -Glycero-3-Phosphoethanolamine-n-(Hexanoylamine) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency suitable for pharmaceutical research and formulation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.