Description

Dofetilide CAS NO 115256-11-6 is a highly selective class III antiarrhythmic agent, functioning as a potent potassium channel blocker. This compound is critical for the development and production of pharmaceutical formulations targeting specific cardiac arrhythmias. It is primarily required by pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and clinical studies.

Application

• Active Pharmaceutical Ingredient (API) in antiarrhythmic medications for the treatment of atrial fibrillation and atrial flutter.
• Reference Standard for analytical method development and validation in quality control laboratories.
• Pharmacological Research for studying cardiac electrophysiology and potassium channel (IKr) function.
• Formulation Development for creating various dosage forms, including tablets and injectables.
• Clinical Trial Material for ongoing research into cardiovascular therapeutics.
• Regulatory Submission batches for new drug applications (NDA) and marketing authorization.

Basic Information

Product Name	Dofetilide
CAS No.	115256-11-6
Molecular Formula	C19H27N3O5S2
Molecular Weight	441.57 g/mol
Synonyms	UK-68,798; N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide; Tikosyn (brand name); (R)-Dofetilide; Sotalol derivative
EINECS	Contact for details

Quality Control

Our Dofetilide is manufactured under strict quality management systems, ensuring compliance with ICH Q7 guidelines for Active Pharmaceutical Ingredients (APIs). Each batch undergoes comprehensive testing including identification, purity assay, and impurity profiling. A Certificate of Analysis (COA) documenting full compliance with agreed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, protect from moisture. Keep container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.