Description

n-(tert-Butoxycarbonyl)-L-Proline N'-Methoxy-N'-Methylamide is a high-purity, protected amino acid derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for the efficient and controlled construction of complex peptide and peptidomimetic structures, offering superior stability and reactivity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other bioactive molecules.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for introducing proline derivatives.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and production of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide-based drugs.
• Bioconjugation & Linker Chemistry: Used in the preparation of peptide-drug conjugates and other bioconjugates due to its reactive amide and protected amine functionalities.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Academic & Industrial Research: A valuable reagent for synthetic organic chemists exploring new methodologies and complex molecular architectures.
• Prodrug Development: The Boc-protecting group and amide functionality make it suitable for designing prodrug strategies to enhance drug bioavailability.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-L-Proline N'-Methoxy-N'-Methylamide
CAS No.	115186-37-3
Molecular Formula	C13H24N2O4
Molecular Weight	272.34 g/mol
Synonyms	Boc-L-Proline-N'-O-Methyl-N-methylhydroxamide; Boc-Pro-NH-OMe; (S)-1-((tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid methoxy(methyl)amide; N-Boc-L-proline N-methoxy-N-methylamide; N-(tert-Butoxycarbonyl)-L-proline N'-methoxy-N'-methylamide; N-Boc-L-Pro-N(OMe)Me; L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-, N-methoxy-N-methylamide
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-L-Proline N'-Methoxy-N'-Methylamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.