Description

Boc-o-Benzyl-L-Serine N,o-Dimethylhydroxamide is a protected serine derivative, a crucial chiral building block in advanced organic synthesis. This compound is specifically engineered to provide orthogonal protection for the amino and hydroxyl functionalities of serine, enabling precise and sequential synthetic manipulations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of complex peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate serine residues with orthogonal protecting groups (Boc and Bn).
• Chemical Biology Probes: Serves as a precursor for synthesizing labeled or modified amino acids used in studying protein function and interactions.
• Medicinal Chemistry: Enables the construction of complex molecular scaffolds for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent in university and institutional labs for methodology development and total synthesis projects.

Basic Information

Item	Detail
Product Name	Boc-o-Benzyl-L-Serine N,o-Dimethylhydroxamide
CAS No.	115186-34-0
Molecular Formula	C17H26N2O5
Molecular Weight	338.40 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-benzyl-L-serine N,O-dimethylhydroxamide; Boc-Ser(Bzl)-N(Me)-O(Me)-OH; tert-Butyl N-[(1S)-1-[[dimethylamino(hydroxy)methylene]amino]-3-(phenylmethoxy)-1-oxopropan-2-yl]carbamate; (S)-2-((tert-Butoxycarbonyl)amino)-3-(benzyloxy)-N,N-dimethylpropanehydroxamic acid; Boc-L-Ser(Bzl)-N(Me)OMe; Boc-O-Benzyl-L-serine dimethylhydroxamate; Protected L-Serine derivative
EINECS	Contact for details

Quality Control

Our Boc-o-Benzyl-L-Serine N,o-Dimethylhydroxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity (HPLC), and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.