Description

n-Boc-D-Phenylalanine N'-Methoxy-N'-Methylamide is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This compound is essential for the efficient and stereoselective construction of complex peptide and peptidomimetic structures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of peptide-based drugs and protease inhibitors.
• Peptidomimetics Research: Used to incorporate modified phenylalanine residues into peptidomimetic scaffolds for drug discovery programs.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected D-phenylalanine derivative for the controlled assembly of peptides with specific stereochemistry.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening against biological targets.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Academic & Institutional Research: A valuable reagent for studies in medicinal chemistry, organic methodology, and chemical biology.

Basic Information

Product Name	n-Boc-D-Phenylalanine N'-Methoxy-N'-Methylamide
CAS No.	115186-33-9
Molecular Formula	C₁₇H₂₆N₂O₄
Molecular Weight	322.40 g/mol
Synonyms	Boc-D-Phe-NH-OMe; tert-Butyl (R)-2-((methoxy(methyl)amino)-2-oxo-1-phenylethyl)carbamate; (R)-2-((tert-Butoxycarbonyl)amino)-3-phenyl-N-methoxy-N-methylpropanamide; D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, N-methoxy-N-methylamide; Boc-D-Phenylalanine Weinreb amide; N-Boc-D-Phenylalanine N,O-Dimethylhydroxylamide; N-(tert-Butoxycarbonyl)-D-phenylalanine N-methoxy-N-methylamide
EINECS	Contact for details

Quality Control

Our n-Boc-D-Phenylalanine N'-Methoxy-N'-Methylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.