Description

Bombesin, Leu(13)-Psi-Ch2Nh-Leu(14)- is a synthetic peptide analog of the neuropeptide bombesin, featuring a reduced peptide bond (Psi-CH2NH) modification. This structural alteration enhances its metabolic stability and receptor binding affinity, making it a critical tool for advanced biomedical research. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, neurobiology, and metabolic studies. This high-purity compound is essential for investigating bombesin receptor signaling pathways and developing novel diagnostic and therapeutic agents.

Application

• Biomedical Research: A key reagent for studying the role of bombesin and its receptors (BB1, BB2, BB3) in various physiological and pathological processes.
• Oncology Research: Used in cancer research to investigate tumor growth, proliferation, and the development of targeted cancer therapies, particularly for prostate, lung, and gastrointestinal cancers.
• Neuropharmacology: Employed in neurological studies to understand satiety signaling, stress responses, and thermoregulation mediated by bombesin-like peptides.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the design and screening of novel bombesin receptor agonists and antagonists.
• In Vitro & In Vivo Assays: Used in receptor binding assays, functional cell-based assays, and animal model studies to validate biological activity and mechanism of action.
• Diagnostic Probe Development: Acts as a precursor for developing radiolabeled (e.g., with 68Ga, 18F) probes for positron emission tomography (PET) imaging of bombesin receptor-positive tumors.

Basic Information

Product Name	Bombesin, Leu(13)-Psi-Ch2Nh-Leu(14)-
CAS No.	115136-07-7
Molecular Formula	C71H106N24O18S
Molecular Weight	1615.8 g/mol
Synonyms	Bombesin (6-14), Leu(13)-psi[CH2NH]-Leu(14)-; [Psi13,14]Bombesin(6-14); Leu13-Psi(CH2NH)-Leu14-Bombesin; Reduced Peptide Bond Bombesin Analog; Bombesin Receptor Ligand; GRP(18-27), Leu(13)-psi[CH2NH]-Leu(14)-; pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-ψ[CH2NH]-Leu-Met-NH2
EINECS	Contact for details

Quality Control

Our Bombesin, Leu(13)-Psi-Ch2Nh-Leu(14)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. For custom synthesis or specific purity requirements (e.g., >98%, >99%), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.