Description

Ibuprofen Acyl-B-D-Glucuronide is a major, pharmacologically relevant metabolite of the widely used non-steroidal anti-inflammatory drug (NSAID) ibuprofen. This compound is crucial for advanced pharmaceutical research and development, particularly in the fields of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It serves as a critical reference standard for scientists and quality control laboratories in the pharmaceutical and biotechnology industries who require high-purity materials for analytical testing and regulatory submissions.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantifying ibuprofen metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and half-life of ibuprofen in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, calibrate, and validate sensitive analytical methods such as LC-MS/MS and HPLC for accurate bioanalysis.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxicological effects of ibuprofen metabolites.
• Impurity Profiling and Characterization: Acts as a known impurity or degradation product standard for the quality control of ibuprofen active pharmaceutical ingredient (API) and finished dosage forms.
• Academic and Contract Research: Serves as a key reagent in university laboratories and CROs (Contract Research Organizations) focused on pharmacology and analytical chemistry.

Basic Information

Product Name	Ibuprofen Acyl-B-D-Glucuronide
CAS No.	115075-59-7
Molecular Formula	C19H26O8
Molecular Weight	382.41 g/mol
Synonyms	Ibuprofen Acyl-β-D-Glucuronide; Ibuprofen Glucuronide; (2S,3S,4S,5R,6S)-6-[(2-(4-Isobutylphenyl)propanoyl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic Acid; 1-O-(Ibuprofenoyl)-β-D-Glucopyranuronic Acid; Ibuprofen 1-O-β-Acyl Glucuronide; Ibuprofen Acyl Glucuronide; IBP-Gluc; Ibuprofen Metabolite
EINECS	Contact for details

Quality Control

Every batch of our Ibuprofen Acyl-B-D-Glucuronide is manufactured and controlled under a strict quality management system. The product undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for research and reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for purity, assay, and impurities. Our quality commitment supports compliance with relevant pharmacopeial guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.