Description

Cnqx CAS NO 115066-14-3 is a selective and potent antagonist for the AMPA/kainate subtype of glutamate receptors. This compound is a critical research tool for neuroscientists, enabling the study of excitatory neurotransmission, neurotoxicity, and synaptic plasticity. It is primarily utilized in academic, pharmaceutical, and biotechnology research focused on neurological disorders, neuropharmacology, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A fundamental tool for studying the role of AMPA and kainate receptors in synaptic transmission, long-term potentiation (LTP), and long-term depression (LTD).
• Neuropharmacology Screening: Used as a reference standard in high-throughput assays to identify and characterize new compounds targeting ionotropic glutamate receptors.
• Neuroprotection Studies: Employed in models of excitotoxicity, stroke, and traumatic brain injury to understand and mitigate glutamate-induced neuronal damage.
• Electrophysiology: Essential for patch-clamp and other electrophysiological experiments to block AMPA/kainate receptor-mediated currents.
• Drug Discovery & Development: Serves as a key pharmacological agent in target validation and mechanistic studies for conditions like epilepsy, ALS, and chronic pain.
• Biochemical Assays: Used in receptor binding studies and other in vitro biochemical tests to determine receptor affinity and selectivity.

Basic Information

Product Name	Cnqx
CAS No.	115066-14-3
Molecular Formula	C9H4N4O3
Molecular Weight	216.15 g/mol
Synonyms	6-Cyano-7-nitroquinoxaline-2,3-dione; CNQX disodium salt; FG-9041; AMPA/kainate receptor antagonist; CNQX hydrate; 6-Cyano-7-nitro-2,3-quinoxalinedione
EINECS	Contact for details

Quality Control

Our Cnqx is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.