Description

Calmodulin-Dependent Protein Kinase II (290-309) is a synthetic peptide fragment corresponding to a specific regulatory region of the CaMKII enzyme. This compound is a critical research tool for studying calcium/calmodulin-dependent signal transduction pathways, which are fundamental to numerous cellular processes. It is primarily utilized by researchers in neuroscience, cardiology, and cell biology for investigating enzyme kinetics, protein-protein interactions, and developing potential therapeutic inhibitors.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study the activity and regulation of CaMKII.
• Neuroscience Studies: Essential for research into synaptic plasticity, memory formation, and neuronal signaling mechanisms.
• Cardiovascular Research: Applied in studies of cardiac muscle contraction, calcium handling, and related disease models.
• Antibody Production: Serves as an immunogen for generating sequence-specific antibodies against CaMKII.
• Cell Signaling Pathway Analysis: A key reagent for dissecting the role of CaMKII in various intracellular signaling cascades.
• Pharmaceutical Development: Used in high-throughput screening and validation for drug discovery programs targeting CaMKII-related disorders.

Basic Information

Product Name	Calmodulin-Dependent Protein Kinase II (290-309)
CAS No.	115044-69-4
Molecular Formula	C96H155N31O26
Molecular Weight	~2099.4 g/mol
Synonyms	CaMKII (290-309); CaMKII Inhibitor Peptide (290-309); Autocamtide-2-related Inhibitory Peptide (AIP); CaM Kinase II Inhibitor (290-309); CaMKII(290-309); CaMKII Substrate Peptide (290-309); Protein Kinase, Calcium/Calmodulin-Dependent, Type II, Inhibitor Peptide (290-309); H-Arg-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Ala-Leu-Arg-Gln-Lys-Glu-Ala-Val-Asp-Ala-Leu-OH
EINECS	Contact for details

Quality Control

Our research-grade peptides are produced under stringent conditions and undergo comprehensive analytical characterization. Each batch is supplied with a detailed Certificate of Analysis (COA) providing data on purity, identity, and composition. We ensure compliance with high standards for biochemical reagent quality, supporting reproducible and reliable scientific results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 70%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.