Description

Tri(2,5-Xylyl)Phosphine is a specialized organophosphorus ligand characterized by its sterically demanding, electron-rich triarylphosphine structure. This compound matters as a highly effective catalyst component in transition metal-catalyzed cross-coupling reactions, where it promotes challenging bond formations with high selectivity and yield. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing complex organic molecules.

Application

• As a ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings.
• Catalyst component for C-H activation and functionalization processes in fine chemical synthesis.
• Used in the development and scale-up of active pharmaceutical ingredients (APIs) and key drug intermediates.
• Facilitates the synthesis of agrochemicals and specialty chemicals requiring robust catalytic systems.
• Employed in academic and industrial research for exploring new catalytic methodologies.
• Potential use in material science for the synthesis of organic electronic materials.

Basic Information

Product Name	Tri(2,5-Xylyl)Phosphine
CAS No.	115034-38-3
Molecular Formula	C24H27P
Molecular Weight	346.44 g/mol
Synonyms	Tris(2,5-dimethylphenyl)phosphine; Tri(2,5-dimethylphenyl)phosphine; Phosphorous tris(2,5-xylyl); Tris(2,5-xylyl)phosphine; 2,5-Xylylphosphine; Ligand QPhos (related class); Sterically hindered triarylphosphine ligand
EINECS	Contact for details

Quality Control

Our Tri(2,5-Xylyl)Phosphine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, critical for catalytic performance. Each lot is analyzed using advanced techniques including NMR and HPLC to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and residual solvent levels is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, containers should be kept sealed and only opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.