Description

Propofol Glucuronide is a major, pharmacologically inactive metabolite of the widely used intravenous anesthetic agent, propofol. This reference standard is critical for analytical and research purposes, enabling the accurate quantification of propofol metabolism in biological samples. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology departments for method development, validation, and quality control in pharmacokinetic studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the calibration and validation of analytical methods (HPLC, LC-MS/MS) used in drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolite Identification & Quantification: Essential for identifying and quantifying propofol glucuronide levels in plasma, urine, and other biological matrices during clinical trials and toxicological assessments.
• Bioanalytical Method Development: Used as a key component in developing robust and sensitive assays to study the metabolic profile and clearance pathways of propofol.
• Forensic and Clinical Toxicology: Employed in forensic labs and hospital settings to confirm propofol exposure, monitor patient metabolism, and investigate potential drug-related incidents.
• Pharmacology Research: Supports fundamental research into the metabolic pathways, enzyme kinetics (UGT enzymes), and potential drug-drug interactions involving propofol.
• Quality Control in Manufacturing: Used by API manufacturers to monitor and control potential metabolite impurities in propofol active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Propofol Glucuronide
CAS No.	114991-26-3
Molecular Formula	C21H30O8
Molecular Weight	410.46 g/mol
Synonyms	2,6-Diisopropylphenol glucuronide; Propofol β-D-Glucuronide; 1-(β-D-Glucopyranosiduronic acid) 2,6-diisopropylphenol; 2,6-Bis(1-methylethyl)phenyl β-D-Glucopyranosiduronic Acid; Propofol Glucuronide (major metabolite); Propofol 1-O-β-D-Glucuronide; 2,6-Diisopropyl-1-O-(β-D-glucopyranosyluronic acid)benzene
EINECS	Contact for details

Quality Control

Our Propofol Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for reference materials, and our quality system supports traceability and reliability for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from moisture absorption. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.