Description

4-Hydroxy Propofol 1-o-B-D-Glucuronide is a major, inactive metabolite of the widely used intravenous anesthetic agent propofol. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism, pharmacokinetic studies, and bioanalytical method validation. It serves as a key reference standard for laboratories conducting clinical trials, forensic toxicology, and therapeutic drug monitoring to ensure accurate quantification of propofol and its metabolites in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods (HPLC, LC-MS/MS) in bioanalysis.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, clearance rates, and excretion profiles of propofol in preclinical and clinical research.
• Clinical Research & Toxicology: Used to accurately measure propofol metabolite levels in patient plasma or serum during anesthesia studies and in forensic investigations.
• Biomarker Research: Investigation into the correlation between metabolite levels and pharmacological effects or potential side effects.
• Quality Control in Manufacturing: Employed by API manufacturers to monitor and control the impurity profile of propofol drug substance.
• Regulatory Submissions: Critical for compiling Investigational New Drug (IND) and New Drug Application (NDA) dossiers submitted to agencies like the FDA and EMA.

Basic Information

Product Name	4-Hydroxy Propofol 1-o-B-D-Glucuronide
CAS No.	114991-25-2
Molecular Formula	C24H32O9
Molecular Weight	464.5 g/mol
Synonyms	Propofol Glucuronide; 1-O-(4-Hydroxy-2,6-diisopropylphenyl)-β-D-glucopyranosiduronic acid; 4-Hydroxy Propofol O-β-D-Glucuronide; 2,6-Diisopropyl-1-(β-D-glucopyranuronosyloxy)-4-hydroxybenzene; Propofol 1-O-Glucuronide; 4-OH Propofol Glucuronide; 1-O-(4-Hydroxy-2,6-diisopropylphenyl)-β-D-glucuronide; 4-Hydroxy-2,6-diisopropylphenyl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Propofol 1-o-B-D-Glucuronide is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation by spectroscopic methods (NMR, MS), and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing all test results and methods are provided to ensure full traceability and compliance with research and pharmaceutical reference standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.