Description

4-Bromo-2-Fluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant commercial and research interest. This compound is valued for its role as a versatile synthetic intermediate in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine substituents modulate biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers where specific halogenated motifs are required.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical reactions in academic laboratories and corporate R&D centers.

Basic Information

Product Name	4-Bromo-2-Fluorophenylacetic Acid
CAS No.	114897-92-6
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	(4-Bromo-2-fluorophenyl)acetic acid; 2-(4-Bromo-2-fluorophenyl)acetic acid; 4-Bromo-2-fluoro-benzeneacetic acid; 4-Bromo-2-fluorophenylacetic acid; p-Bromo-o-fluorophenylacetic acid; 2-(4-Brom-2-fluor-phenyl)essigsäure (German); Acide (4-bromo-2-fluorophényl)acétique (French)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorophenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.