Description

Boc-D-3-Fluorophe CAS NO 114873-11-9 is a high-purity, protected amino acid derivative, specifically the N-tert-butoxycarbonyl (Boc) derivative of D-3-fluorophenylalanine. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex peptides and bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of therapeutic peptides.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting specific enzymes.
• Peptidomimetics: Incorporation into non-natural peptide analogs to improve pharmacological properties such as bioavailability and target selectivity.
• Chemical Biology Probes: Serves as a building block for creating labeled peptides and activity-based probes for studying biological mechanisms.
• API Synthesis: Employed in the synthetic pathway of active pharmaceutical ingredients (APIs) that require fluorinated phenylalanine motifs.
• Academic & Industrial R&D: Essential for medicinal chemistry programs in both academic research laboratories and industrial drug discovery pipelines.

Basic Information

Product Name	Boc-D-3-Fluorophe CAS NO 114873-11-9
CAS No.	114873-11-9
Molecular Formula	C₁₄H₁₈FNO₄
Molecular Weight	283.30 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(3-fluorophenyl)propanoic acid; N-Boc-D-3-Fluorophenylalanine; Boc-D-3-F-Phe-OH; N-(tert-Butoxycarbonyl)-3-fluoro-D-phenylalanine; Boc-3-F-D-Phe; tert-Butyl (R)-(3-(3-fluorophenyl)-1-hydroxy-1-oxopropan-2-yl)carbamate; D-3-Fluorophenylalanine N-Boc derivative
EINECS	Contact for details

Quality Control

Our Boc-D-3-Fluorophe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.