Description

Boc-D-2-Fluorophe CAS NO 114873-10-8 is a protected, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a fluorine atom on the aromatic ring. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex peptides and peptidomimetics with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents, particularly in oncology, neurology, and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of fluorinated bioactive peptides.
• Protease Inhibitor Development: Used to incorporate fluorinated phenylalanine analogs into peptide backbones to create potent and selective enzyme inhibitors.
• PET Tracer Precursor: Serves as a precursor in the radiochemical synthesis of fluorine-18 labeled compounds for Positron Emission Tomography (PET) imaging.
• Peptidomimetic Research: Essential for constructing peptide analogs where the fluorine atom modulates lipophilicity, electronic properties, and receptor binding affinity.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in asymmetric synthesis and peptide chemistry.
• Agrochemical Research: Potential intermediate for developing novel fluorinated peptide-based bioactive compounds.

Basic Information

Product Name	Boc-D-2-Fluorophe CAS NO 114873-10-8
CAS No.	114873-10-8
Molecular Formula	C₁₄H₁₈FNO₄
Molecular Weight	283.30 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-2-fluorophenylalanine; Boc-D-2-Fluoro-Phe-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)propanoic acid; Boc-D-2-Fluorophenylalanine; N-Boc-D-2-fluorophenylalanine; Boc-D-Phe(2-F)-OH; D-2-Fluorophenylalanine N-Boc derivative; BOC-D-2-F-PHE
EINECS	Contact for details

Quality Control

Our Boc-D-2-Fluorophe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including GMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.